Structure via PubChem · Public domain (PubChem)
地诺帕明
Sign in to saveAlso known as (R)-(-)-denopamine, 4-[(1R)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol
化合物
In the Vinony graph
Vinony's link graph records 1,857 inbound references to 地诺帕明, and connects out to adrenergic receptor, propranolol and atenolol.
It sits within the topics 4-Hydroxyphenyl compounds, Beta1-adrenergic agonists and Catechol ethers.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C18H23NO4
- Molecular weight
- 317.4 g/mol
- IUPAC name
- 4-[(1R)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol
- SMILES
- COC1=C(C=C(C=C1)CCNC[C@@H](C2=CC=C(C=C2)O)O)OC
- InChIKey
- VHSBBVZJABQOSG-INIZCTEOSA-N
- XLogP
- 1.8
- Polar surface area
- 71 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
151 papers- Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator.Current medical research and opinion · 2002
- Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart.Journal of the American College of Cardiology · 1998
- Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs.Journal of applied physiology (Bethesda, Md. : 1985) · 2001
- [Denopamine responsive pulmonary hypertension in a patient with collagen disease].Ryumachi. [Rheumatism] · 1989
- Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform.Drug metabolism and disposition: the biological fate of chemicals · 2005
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 317.162708
Show 5 more facts
- chemical formula
- C₁₈H₂₃NO₄
- canonical SMILES
- COC1=C(C=C(C=C1)CCNCC(C2=CC=C(C=C2)O)O)OC
- subject has role
- cardiotonic
- isomeric SMILES
- COC1=C(C=C(C=C1)CCNC[C@@H](C2=CC=C(C=C2)O)O)OC
- Commons category
- Denopamine
Sources (2)
via Wikidata · CC0
Connections
adrenergic receptor
Entity
propranolol
Entity
atenolol
Entity
sympathomimetic drug
Entity
labetalol
Entity
levobunolol
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exaprolol
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Japan
Country
medication
Entity
circulatory system
Entity
digital object identifier
Entity
chemical formula
Entity
epinephrine
Entity
heart failure
Entity
dopamine
Entity
molar mass
Entity
angina pectoris
Entity
PubMed
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phenylalanine
Entity
L-tyrosine
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