DHPS

Also known as deoxyhypusine synthase, DHS, DS, MIG13, NEDSSWI

Deoxyhypusine synthase is an enzyme that in humans is encoded by the DHPS gene.

Gene data

DHPS

Name: deoxyhypusine synthase
Type: protein-coding
Position: 12,673,411–12,681,894 (−)
Aliases: DHS, DS, MIG13, NEDSSWI
Ensembl: ENSG00000095059
RefSeq RNA: NM_001206974.2, NM_001369691.1, NM_001369692.1, NM_001369693.1, NM_001930.4
RefSeq protein: NP_001193903.1, NP_001356620.1, NP_001356621.1, NP_001356622.1, NP_001921.1

This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011].

Gene Ontology

Biological process

translation spermidine metabolic process spermidine metabolic process positive regulation of cell population proliferation peptidyl-hypusine biosynthetic process spermidine catabolic process protein maturation

Molecular function

protein binding deoxyhypusine synthase activity deoxyhypusine synthase activity deoxyhypusine synthase activity identical protein binding identical protein binding

Cellular component

cytoplasm cytosol cytosol

Pathways

Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Hypusine synthesis from eIF5A-lysine Metabolism of proteins Post-translational protein modification

via MyGene.info

Gene · Ensembl

deoxyhypusine synthase

Symbol: DHPS
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:12,673,411-12,681,901
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein DHPS PDB 1dhs.png

Show 5 more facts

HomoloGene ID: 1453
exact match: identifiers.org/ncbigene/1725
genomic start: 12786531
genomic end: 12681880
cytogenetic location: 19p13.13

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Deoxyhypusine synthase is an enzyme that in humans is encoded by the DHPS gene.

The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A (EIF5A, EIF5A2). In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity.