Structure via PubChem · Public domain (PubChem)
difemetorex
Sign in to saveAlso known as diphemethoxidine
Difemetorex (INN) or diphemethoxidine (USAN) is a central nervous system (CNS) stimulant drug introduced in France in 1966 by the pharmaceutical company, Ciba-Geigy; it was briefly used as an appetite suppressant and weight loss aid into the early 1970s, sold under the brand name Cleofil. A member of the piperidine chemical class, difemetorex was described as having such a disruptive and intolerable side effect of insomnia that patient drug compliance suffered and frequency of clinical use decreased, resulting in withdrawal from the market and cessation of production, availability, accessibili
Chemical data
- Formula
- C20H25NO
- Molecular weight
- 295.4 g/mol
- IUPAC name
- 2-(2-benzhydrylpiperidin-1-yl)ethanol
- SMILES
- C1CCN(C(C1)C(C2=CC=CC=C2)C3=CC=CC=C3)CCO
- InChIKey
- UHZJPVXMMCFPNR-UHFFFAOYSA-N
- XLogP
- 3.9
- Polar surface area
- 23.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 295.194
Show 3 more facts
- chemical formula
- C₂₀H₂₅NO
- canonical SMILES
- C1CCN(C(C1)C(C2=CC=CC=C2)C3=CC=CC=C3)CCO
- Commons category
- Difemetorex
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Difemetorex (INN) or diphemethoxidine (USAN) is a central nervous system (CNS) stimulant drug introduced in France in 1966 by the pharmaceutical company, Ciba-Geigy; it was briefly used as an appetite suppressant and weight loss aid into the early 1970s, sold under the brand name Cleofil. A member of the piperidine chemical class, difemetorex was described as having such a disruptive and intolerable side effect of insomnia that patient drug compliance suffered and frequency of clinical use decreased, resulting in withdrawal from the market and cessation of production, availability, accessibility, and overall recognition among related substances. It is only known to have been marketed in France, and has remained virtually non-existent in the current era.
thumb|center|500px|class=skin-invert-image|Synthesis of difemetorex
Excerpted from Wikipedia’s “difemetorex” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0