diphthamide
Sign in to saveAlso known as (2S)-2-amino-3-[2-[(3S)-4-amino-4-oxo-3-(trimethylazaniumyl)butyl]-1H-imidazol-5-yl]propanoate
Diphthamide is a post-translationally modified histidine amino acid found in archaeal and eukaryotic elongation factor 2 (eEF-2).
Wikidata facts
- Mass
- 298.18736604809
Show 3 more facts
- canonical SMILES
- C[N+](C)(C)C(CCC1=NC=C(N1)CC(C(=O)O)N)C(=O)N
- isomeric SMILES
- C[N+](C)(C)[C@@H](CCC1=NC=C(N1)C[C@@H](C(=O)O)N)C(=O)N
- chemical formula
- C₁₃H₂₄N₅O₃⁺
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Article
3 sectionsContents
- Structure and biosynthesis
- Biological function
- References
Diphthamide is a post-translationally modified histidine amino acid found in archaeal and eukaryotic elongation factor 2 (eEF-2).
Dipthamide is named after the toxin produced by the bacterium Corynebacterium diphtheriae, which targets diphthamide. Besides this toxin, it is also targeted by exotoxin A from Pseudomonas aeruginosa. It is the only target of these toxins.
Connections
amino acid
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digital object identifier
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chemical formula
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molar mass
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Q180686
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bibcode
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L-histidine
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amides
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CAS Registry Number
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Q229883
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translation
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PubChem
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X-ray crystallography
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imidazole
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simplified molecular input line entry specification
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methyl
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chemical nomenclature
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Q2311683
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Pseudomonas aeruginosa
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Corynebacterium diphtheriae
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