DMTF1

Also known as DMP1, DMTF, MRUL, hDMP1, cyclin D binding myb like transcription factor 1

Cyclin-D-binding Myb-like transcription factor 1 is a protein that in humans is encoded by the DMTF1 gene.

Gene data

DMTF1

Name: cyclin D binding myb like transcription factor 1
Type: protein-coding
Position: 87,152,409–87,196,337 (+)
Aliases: DMP1, DMTF, MRUL, hDMP1
Ensembl: ENSG00000135164
RefSeq RNA: NM_001142326.2, NM_001142327.2, NM_021145.4, NR_024549.2, NR_024550.2
RefSeq protein: NP_001135798.1, NP_001135799.1, NP_066968.3, XP_011515039.1, XP_011515041.1

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].