DOT1L

Also known as DOT1, KMT4, DOT1 like histone lysine methyltransferase

DOT1-like (Disruptor of telomeric silencing 1-like), histone H3K79 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.

Gene data

DOT1L

Name: DOT1 like histone lysine methyltransferase
Type: protein-coding
Position: 2,163,933–2,232,578 (+)
Aliases: DOT1, KMT4, NDNS
Ensembl: ENSG00000104885
RefSeq RNA: NM_001411141.1, NM_032482.3, XM_011528359.3, XM_011528361.3, XM_047439513.1
RefSeq protein: NP_001398070.1, NP_115871.1, XP_011526661.1, XP_011526663.1, XP_047295469.1

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011].

Pathways

Lysine degradation - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)PKMTs methylate histone lysines Chromatin modifying enzymes Chromatin organization Histone Modifications

via MyGene.info

Gene · Ensembl

DOT1 like histone lysine methyltransferase

Symbol: DOT1L
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:2,163,933-2,232,578
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein DOT1L PDB 1nw3.png

Show 8 more facts

HomoloGene ID: 32779
genetic association: osteoarthritis
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/84444
genomic end: 2232577
genomic start: 2163933
chromosome: human chromosome 19
cytogenetic location: 19p13.3

Sources (5)

via Wikidata · CC0

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Encyclopedic overview

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Contents

References
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DOT1-like (Disruptor of telomeric silencing 1-like), histone H3K79 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.

DOT1L has been reported to play an important role in the processes of mixed-lineage leukemia (MLL)-rearranged leukemias. DOT1L also plays a role in spermatogenesis, where it acts as a transcriptional activator for genes responsible for the histone-to-protamine transition.

Excerpted from Wikipedia’s “DOT1L” article, available under the CC BY-SA 4.0 licence.