DOT1L

Also known as DOT1, KMT4, DOT1 like histone lysine methyltransferase

DOT1-like (Disruptor of telomeric silencing 1-like), histone H3K79 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.

Gene data

DOT1L

Name: DOT1 like histone lysine methyltransferase
Type: protein-coding
Aliases: DOT1, KMT4, NDNS

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011].

via MyGene.info

Gene · Ensembl

DOT1 like histone lysine methyltransferase

Symbol: DOT1L
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:2,163,933-2,232,578
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein DOT1L PDB 1nw3.png

Show 5 more facts

HomoloGene ID: 32779
exact match: identifiers.org/ncbigene/84444
genomic end: 2232577
genomic start: 2163933
cytogenetic location: 19p13.3

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DOT1-like (Disruptor of telomeric silencing 1-like), histone H3K79 methyltransferase (S. cerevisiae), also known as DOT1L, is a protein found in humans, as well as other eukaryotes.

DOT1L has been reported to play an important role in the processes of mixed-lineage leukemia (MLL)-rearranged leukemias. DOT1L also plays a role in spermatogenesis, where it acts as a transcriptional activator for genes responsible for the histone-to-protamine transition.