DRAP1
Sign in to saveAlso known as NC2-alpha, DR1 associated protein 1
Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene.
Gene data
DRAP1- Name
- DR1 associated protein 1
- Type
- protein-coding
- Position
- 65,919,274–65,921,563 (+)
- Aliases
- NC2-alpha
- Ensembl
- ENSG00000175550
- RefSeq RNA
- NM_006442.4
- RefSeq protein
- NP_006433.2
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
DR1 associated protein 1
- Symbol
- DRAP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:65,919,258-65,921,565
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein DRAP1 PDB 1jfi.png
Show 5 more facts
- HomoloGene ID
- 4703
- exact match
- identifiers.org/ncbigene/10589
- genomic start
- 65919274
- genomic end
- 65921563
- cytogenetic location
- 11q13.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Interactions
- References
- Further reading
Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene.
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.