ERLIN2

Name

ER lipid raft associated 2

Type

protein-coding

Aliases

C8orf2, Erlin-2, NET32, SPFH2, SPG18, SPG18A, SPG18B

This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].

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Gene · Ensembl

ER lipid raft associated 2

Symbol

ERLIN2

Biotype

Protein coding

Organism

Homo sapiens

Location

8:37,736,587-37,758,422

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

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