ethisterone
Sign in to saveAlso known as 17alpha-Ethynyl-17beta-hydroxyandrost-4-en-3-one, Progestolets, 17alpha-Ethinyl testosterone, 17-ethynyl-17beta-hydroxyandrost-4-en-3-one, 17-beta-hydroxy-17-alpha-ethynyl-4-androsten-3-one, 17-hydroxy-17alpha-pregn-4-en-20-yn-3-one, 17alpha-ethinyltestosterone, aethisteronum
Ethisterone, also known as ethinyltestosterone, pregneninolone, and anhydrohydroxyprogesterone and formerly sold under the brand names Proluton C and Pranone among others, is a progestin medication which was used in the treatment of gynecological disorders but is now no longer available. It was used alone and was not formulated in combination with an estrogen. The medication is taken by mouth.
Research
259 papers- Microbial transformation of oral contraceptive ethisterone by Aspergillus niger and Cunninghamella blakesleeana.Steroids · 2020
- (18)F-labeled ethisterone derivative for progesterone receptor targeted PET imaging of breast cancer.Nuclear medicine and biology · 2019
- Novel C,N-chelate platinum(II) antitumor complexes bearing a lipophilic ethisterone pendant.Journal of inorganic biochemistry · 2011
- Progesterone and ethisterone.The Practitioner · 1958
- Androgen receptor antagonism by divalent ethisterone conjugates in castrate-resistant prostate cancer cells.ACS chemical biology · 2012
via PubMed
Wikidata facts
- Mass
- 312.20893
Show 6 more facts
- chemical formula
- C₂₁H₂₈O₂
- canonical SMILES
- CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4(C#C)O)C
- isomeric SMILES
- C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@]4(C#C)O)C
- World Health Organisation international non-proprietary name
- ethisterone
- Commons category
- Ethisterone
- defined daily dose
- 5
via Wikidata · CC0
~9 min read
Article
21 sectionsContents
- Medical uses
- Available forms
- Side effects
- Pharmacology
- Pharmacodynamics
- Progestogenic activity
- Androgenic activity
- Estrogenic activity
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Chemistry
- Synthesis
- History
- Society and culture
- Generic names
- Brand names
- Availability
- References
- Further reading
Ethisterone, also known as ethinyltestosterone, pregneninolone, and anhydrohydroxyprogesterone and formerly sold under the brand names Proluton C and Pranone among others, is a progestin medication which was used in the treatment of gynecological disorders but is now no longer available. It was used alone and was not formulated in combination with an estrogen. The medication is taken by mouth.
Side effects of ethisterone include masculinization among others. Ethisterone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has some androgenic and anabolic activity and no other important hormonal activity.