FCRL4

Also known as CD307d, FCRH4, IGFP2, IRTA1, Fc receptor like 4

Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene. FCRL4 is an inhibitory receptor expressed on human memory B cells which resides in epithelial tissues.

Gene data

FCRL4

Name: Fc receptor like 4
Type: protein-coding
Position: 157,573,747–157,598,085 (−)
Aliases: CD307d, FCRH4, IGFP2, IRTA1
Ensembl: ENSG00000163518
RefSeq RNA: NM_031282.3, XM_011510034.2, XM_054338965.1
RefSeq protein: NP_112572.1, XP_011508336.1, XP_054194940.1

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009].

Gene Ontology

Biological process

immune response

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Article

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Contents

References
Further reading

Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene. FCRL4 is an inhibitory receptor expressed on human memory B cells which resides in epithelial tissues.

==References==