Structure via PubChem · Public domain (PubChem)
fenofibrate
Sign in to saveAlso known as 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid 1-methylethyl ester, isopropyl [4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl]propionate, isopropyl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionate
Fenofibrate, sold under the brand name Tricor among others, is an oral medication of the fibrate class used to treat abnormal blood lipid levels. It is less commonly used compared to statins because it treats a different type of cholesterol abnormality than statins. While statins have strong evidence for reducing heart disease and death, there is evidence to suggest that fenofibrate also reduces the risk of heart disease and death. However, this seems only to apply to specific populations of people with elevated triglyceride levels and reduced high-density lipoprotein (HDL) cholesterol. Its us
Key facts
- Drug.IUPHAR_ligand
- 7186
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 459443965
- Drug.image
- fenofibrate structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.tradename
- Tricor, others
- Drug.MedlinePlus
- a601052
- Drug.DailyMedID
- Fenofibrate
- Drug.pregnancy_AU
- B3
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- C10
- Drug.ATC_suffix
- AB05
- Drug.legal_AU
- S4
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.protein_bound
- 99%
via Wikipedia infobox
Chemical data
- Formula
- C20H21ClO4
- Molecular weight
- 360.8 g/mol
- IUPAC name
- propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
- SMILES
- CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
- InChIKey
- YMTINGFKWWXKFG-UHFFFAOYSA-N
- XLogP
- 5.2
- Polar surface area
- 52.6 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
4,875 papersvia PubMed
Wikidata facts
- Mass
- 360.113
Show 6 more facts
- defined daily dose
- 0.2
- chemical formula
- C₂₀H₂₁ClO₄
- canonical SMILES
- CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
- NCI Thesaurus ID
- C29047
- MCN code
- 2918.99.91
- Commons category
- Fenofibrate
via Wikidata · CC0
~11 min read
Article
15 sectionsContents
- Medical uses
- Severe hypertriglyceridemia type IV or V
- Contraindications
- Adverse effects
- Precautions
- Overdose
- Interactions
- Mechanism of action
- Formulations
- Environmental presence
- History
- Society and culture
- Brand names
- Research
- References
Fenofibrate, sold under the brand name Tricor among others, is an oral medication of the fibrate class used to treat abnormal blood lipid levels. It is less commonly used compared to statins because it treats a different type of cholesterol abnormality than statins. While statins have strong evidence for reducing heart disease and death, there is evidence to suggest that fenofibrate also reduces the risk of heart disease and death. However, this seems only to apply to specific populations of people with elevated triglyceride levels and reduced high-density lipoprotein (HDL) cholesterol. Its use is recommended together with dietary changes.
Common side effects include liver problems, breathing problems, abdominal pain, muscle problems, and nausea. Serious side effects may include toxic epidermal necrolysis, rhabdomyolysis, gallstones, and pancreatitis. Use during pregnancy and breastfeeding is not recommended. It works by multiple mechanisms.