fenoldopam

Also known as SK&F-82526J, SK-82526-J

Fenoldopam, sold under the brand name Corlopam, is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist. Fenoldopam is used as an antihypertensive agent. It was approved by the US Food and Drug Administration (FDA) in September 1997.

Key facts

Drug.O: 3
Drug.ATC_suffix: CA19
Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 461099753
Drug.IUPAC_name: (RS)-6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Drug.image: Fenoldopam.svg
Drug.image_class: skin-invert-image
Drug.width: 200px
Drug.image2: Fenoldopam 3d balls.png
Drug.image_class2: bg-transparent
Drug.chirality: Racemic mixture
Drug.tradename: Corlopam
Drug.pregnancy_US: B
Drug.legal_US: Rx-only
Drug.routes_of_administration: Intravenous
Drug.metabolism: Hepatic (CYP not involved)
Drug.elimination_half life: 5 minutes

via Wikipedia infobox

Research

893 papers

Fenoldopam for preventing and treating acute kidney injury.The Cochrane database of systematic reviews · 2024
Fenoldopam Mesylate: A Narrative Review of Its Use in Acute Kidney Injury.Current pharmaceutical biotechnology · 2019
Does Fenoldopam Protect Kidney in Cardiac Surgery? A Systemic Review and Meta-Analysis With Trial Sequential Analysis.Shock (Augusta, Ga.) · 2019
Fenoldopam to prevent acute kidney injury after major surgery-a systematic review and meta-analysis.Critical care (London, England) · 2015
Fenoldopam: a review of its pharmacodynamic and pharmacokinetic properties and intravenous clinical potential in the management of hypertensive urgencies and emergencies.Drugs · 1997

via PubMed

~3 min read

Encyclopedic overview

6 sections

Contents

Medical uses
Contraindications
Adverse effects
Pharmacology
See also
References

== Medical uses == Fenoldopam is used as an antihypertensive agent postoperatively, and also intravenously to treat a hypertensive crisis. Since fenoldopam is an intravenous agent with minimal adrenergic effects that improves renal perfusion, in theory it could be beneficial in hypertensive patients with concomitant chronic kidney disease. It can cause reflex tachycardia, but it is dependent on the infusion of the drug.

Excerpted from Wikipedia’s “fenoldopam” article, available under the CC BY-SA 4.0 licence.

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