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gacyclidine
Sign in to saveGacyclidine (GK-11, OTO-313) is a psychoactive drug which acts as a dissociative via functioning as a non-competitive NMDA receptor antagonist. It is closely related to phencyclidine (PCP), and specifically, is a derivative of tenocyclidine (TCP). Gacyclidine exhibits neuroprotective effects similar to those of other NMDA receptor antagonists, with the advantage of being substantially less neurotoxic maybe due to its interaction with "non-NMDA" binding sites.
Chemical data
- Formula
- C16H25NS
- Molecular weight
- 263.4 g/mol
- IUPAC name
- 1-[(1R,2S)-2-methyl-1-thiophen-2-ylcyclohexyl]piperidine
- SMILES
- C[C@H]1CCCC[C@@]1(C2=CC=CS2)N3CCCCC3
- InChIKey
- DKFAAPPUYWQKKF-GOEBONIOSA-N
- XLogP
- 4.4
- Polar surface area
- 31.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 263.171
Show 4 more facts
- chemical formula
- C₁₆H₂₅NS
- canonical SMILES
- CC1CCCCC1(C2=CC=CS2)N3CCCCC3
- isomeric SMILES
- C[C@H]1CCCC[C@@]1(C2=CC=CS2)N3CCCCC3
- Commons category
- Gacyclidine
Sources (1)
via Wikidata · CC0
~5 min read
Encyclopedic overview
8 sectionsContents
- History
- Chemistry
- Uses
- Dosage
- Effects
- See also
- References
- External links
Gacyclidine (GK-11, OTO-313) is a psychoactive drug which acts as a dissociative via functioning as a non-competitive NMDA receptor antagonist. It is closely related to phencyclidine (PCP), and specifically, is a derivative of tenocyclidine (TCP). Gacyclidine exhibits neuroprotective effects similar to those of other NMDA receptor antagonists, with the advantage of being substantially less neurotoxic maybe due to its interaction with "non-NMDA" binding sites.
== History ==
Excerpted from Wikipedia’s “gacyclidine” article, available under the CC BY-SA 4.0 licence.