GLDC
Sign in to saveAlso known as GCE, GCSP, HYGN1, Glycine dehydrogenase, glycine decarboxylase
protein-coding gene in the species Homo sapiens
Gene data
GLDC- Name
- glycine decarboxylase
- Type
- protein-coding
- Position
- 6,532,467–6,645,729 (−)
- Aliases
- GCE, GCE1, GCSP, HYGN1
- Ensembl
- ENSG00000178445
- RefSeq RNA
- NM_000170.3
- RefSeq protein
- NP_000161.2
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
glycine decarboxylase
- Symbol
- GLDC
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:6,532,464-6,645,734
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 141
- genomic end
- 6645650
- exact match
- identifiers.org/ncbigene/2731
- genomic start
- 6532467
- cytogenetic location
- 9p24.1
Sources (8)
via Wikidata · CC0