GLDC
Sign in to saveAlso known as GCE, GCSP, HYGN1, Glycine dehydrogenase, glycine decarboxylase
protein-coding gene in the species Homo sapiens
In the Vinony graph
Within Vinony's link graph, GLDC is referenced by 12 other articles, and connects out to PubMed, PubMed Central and Gene Ontology.
It sits within the topics EC 1.4.4, Enzymes of known structure and Genes on human chromosome 9.
Its subject is documented across 9 Wikipedia language editions.
Gene data
GLDC- Name
- glycine decarboxylase
- Type
- protein-coding
- Position
- 6,532,464–6,645,734 (−)
- Aliases
- GCE, GCE1, GCSP, HYGN1
- Ensembl
- ENSG00000178445
- RefSeq RNA
- NM_000170.3
- RefSeq protein
- NP_000161.2
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
glycine decarboxylase
- Symbol
- GLDC
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:6,532,464-6,645,734
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 141
- genomic end
- 6645650
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/2731
- genomic start
- 6532467
- chromosome
- human chromosome 9
- cytogenetic location
- 9p24.1
- genetic association
- glycine encephalopathy
- expressed in
- embryo
Sources (8)
via Wikidata · CC0