Also known as GLE1L, LCCS, LCCS1, hGLE1, GLE1, RNA export mediator, GLE1 RNA export mediator, CAAHC, CAAHD
Nucleoporin GLE1 is a protein that in humans is encoded by the GLE1 gene on chromosome 9.
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Biological process
~1 min read
Nucleoporin GLE1 is a protein that in humans is encoded by the GLE1 gene on chromosome 9.
== Function ==
via MyGene.info
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).