GLRX
Sign in to saveAlso known as GRX, GRX1, glutaredoxin
Glutaredoxin-1 is a protein that in humans is encoded by the GLRX gene.
Gene data
GLRX- Name
- glutaredoxin
- Type
- protein-coding
- Aliases
- GRX, GRX1
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011].
via MyGene.info
Gene · Ensembl
glutaredoxin
- Symbol
- GLRX
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:95,735,261-95,822,953
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein GLRX PDB 1b4q.png
Show 5 more facts
- HomoloGene ID
- 37566
- exact match
- identifiers.org/ncbigene/2745
- genomic end
- 95158709
- genomic start
- 95087023
- cytogenetic location
- 5q15
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Interactions
- References
- Further reading
Glutaredoxin-1 is a protein that in humans is encoded by the GLRX gene.
==Interactions== GLRX has been shown to interact with Wilson disease protein and ATP7A.