GPBP1

Name

GC-rich promoter binding protein 1

Type

protein-coding

Position

57,173,821–57,265,668 (+)

Aliases

GPBP, SSH6, VASCULIN

Ensembl

ENSG00000062194

RefSeq RNA

NM_001127235.2, NM_001127236.2, NM_001203246.2, NM_001331037.2, NM_022913.4

RefSeq protein

NP_001120707.2, NP_001120708.1, NP_001190175.1, NP_001317966.1, NP_075064.1

This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].