GPBP1

Also known as GPBP, SSH6, VASCULIN, GC-rich promoter binding protein 1

Vasculin is a protein that in humans is encoded by the GPBP1 gene.

In the Vinony graph

Within Vinony's link graph, GPBP1 is referenced by 2 other articles, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 5.

Its subject is documented across 7 Wikipedia language editions.

Gene data

GPBP1

Name: GC-rich promoter binding protein 1
Type: protein-coding
Position: 57,173,821–57,265,668 (+)
Aliases: GPBP, SSH6, VASCULIN
Ensembl: ENSG00000062194
RefSeq RNA: NM_001127235.2, NM_001127236.2, NM_001203246.2, NM_001331037.2, NM_022913.4
RefSeq protein: NP_001120707.2, NP_001120708.1, NP_001190175.1, NP_001317966.1, NP_075064.1

This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].