H2BC15

Also known as H2B/d, H2BFD, histone cluster 1, H2bn, histone cluster 1 H2B family member n, H2B clustered histone 15, HIST1H2BN

Histone H2B type 1-N is a protein that in humans is encoded by the HIST1H2BN gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to H2BC15, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 6.

Vinony links it to 6 Wikipedia language editions.

Gene data

H2BC15

Name: H2B clustered histone 15
Type: protein-coding
Position: 27,838,545–27,855,879 (+)
Aliases: H2B/d, H2BFD, HIST1H2BN
Ensembl: ENSG00000233822
RefSeq RNA: NM_003520.4
RefSeq protein: NP_003511.1

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].

Gene Ontology

Biological process

innate immune response in mucosa chromatin organization nucleosome assembly antibacterial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide

Molecular function

DNA binding DNA binding DNA binding structural constituent of chromatin structural constituent of chromatin protein heterodimerization activity

Cellular component

nucleosome nucleosome nucleosome extracellular region nucleus nucleus nucleus nucleus

Pathways

Neutrophil extracellular trap formation - Homo sapiens (human)Alcoholism - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)Systemic lupus erythematosus - Homo sapiens (human)Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine

via MyGene.info

Gene · Ensembl

H2B clustered histone 15

Symbol: H2BC15
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:27,838,545-27,855,879
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein Xenopus laevis nucleosome (46) PDB 1aoi.png

Show 7 more facts

HomoloGene ID: 135961
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/8341
genomic end: 27855709
genomic start: 27838545
chromosome: human chromosome 6
cytogenetic location: 6p22.1

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

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Contents

References
Further reading

Histone H2B type 1-N is a protein that in humans is encoded by the HIST1H2BN gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

Excerpted from Wikipedia’s “H2BC15” article, available under the CC BY-SA 4.0 licence.