H2BC5

Also known as H2B.1B, H2B/b, H2BFB, HIRIP2, dJ221C16.6, histone cluster 1, H2bd, histone cluster 1 H2B family member d, H2BFG

Histone H2B type 1-D is a protein that in humans is encoded by the HIST1H2BD gene.

Gene data

H2BC5

Name: H2B clustered histone 5
Type: protein-coding
Position: 26,158,122–26,171,349 (+)
Aliases: H2B.1B, H2B/a, H2B/b, H2B/g, H2B/h, H2B/k, H2B/l, H2BFA, H2BFB, H2BFG
Ensembl: ENSG00000158373
RefSeq RNA: NM_021063.4, NM_138720.2, XM_005249039.5
RefSeq protein: NP_066407.1, NP_619790.1, XP_005249096.2

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].

Gene Ontology

Biological process

innate immune response in mucosa chromatin organization antibacterial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide

Molecular function

DNA binding DNA binding protein binding structural constituent of chromatin structural constituent of chromatin protein heterodimerization activity

Cellular component

nucleosome nucleosome extracellular region nucleus nucleus nucleus nucleus nucleoplasm

Pathways

Neutrophil extracellular trap formation - Homo sapiens (human)Alcoholism - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)Systemic lupus erythematosus - Homo sapiens (human)Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine

via MyGene.info

Gene · Ensembl

H2B clustered histone 5

Symbol: H2BC5
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:26,158,122-26,171,349
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 134740
exact match: identifiers.org/ncbigene/3017
genomic end: 26171577
genomic start: 26158122
cytogenetic location: 6p22.2

Sources (4)

via Wikidata · CC0

~1 min read

Article

2 sections

Contents

References
Further reading

Histone H2B type 1-D is a protein that in humans is encoded by the HIST1H2BD gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryote. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3.