haptoglobin
Sign in to saveAlso known as binding peptide, haptoglobin, alpha polypeptide, haptoglobin alpha(1S)-beta, zonulin, haptoglobin alpha(2FS)-beta, haptoglobin, beta polypeptide, HP
thumbnail|A model of α,β-hemoglobin/haptoglobin hexamer complex. There are 2 α,β-hemoglobin dimers depicted: one space filling model (yellow/orange), and one ribbon model (purple/blue). Each is bound by a haptoglobin molecule (both haptoglobin molecules are shown in pink, with one as a space filling model and one as a ribbon model).
Protein · UniProt
Haptoglobin
- Gene
- HP
- Organism
- Homo sapiens (Human)
- Length
- 406 aa
- Molecular mass
- 45,205 Da
- Evidence
- 1: Evidence at protein level
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
55 registered- COMPLETEDHaptoglobin Phenotype and Cardiovascular Complications in Diabetic PatientsDr. Shany Blum · NCT00448487
- NACOMPLETEDİmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth ZonulinDr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · NCT06200129
- ENROLLING_BY_INVITATIONLactose Intolerance and Intestinal PermabilityBezmialem Vakif University · NCT07424898
- NANOT_YET_RECRUITINGHaemoglobin And Vancomycin Pharmacokinetics in the Cerebrospinal Fluid Following Subarachnoid HaemorrhageUniversity Hospital Southampton NHS Foundation Trust · NCT06373640
- NARECRUITINGThe Impacts of Gluten-free Diet in Patients With Ankylosing SpondylitisSaglik Bilimleri Universitesi · NCT07166874
- UNKNOWNA Diagnostic Accuracy Study Testing Fecal Biomarkers In Comparison To Endoscopic ExaminationUniversität Duisburg-Essen · NCT04849936
Wikidata facts
- Image
- Haptoglobin from 6tb2.png
Show 1 more fact
- exact match
- purl.uniprot.org/uniprot/P00738
via Wikidata · CC0
~8 min read
Article
12 sectionsContents
- Function
- Difference from hemopexin
- Synthesis
- Structure
- In other species
- Clinical significance
- Test protocol
- Interpretation
- See also
- References
- Further reading
- External links
thumbnail|A model of α,β-hemoglobin/haptoglobin hexamer complex. There are 2 α,β-hemoglobin dimers depicted: one space filling model (yellow/orange), and one ribbon model (purple/blue). Each is bound by a haptoglobin molecule (both haptoglobin molecules are shown in pink, with one as a space filling model and one as a ribbon model).
Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds with high affinity to free hemoglobin released from erythrocytes, and thereby inhibits its deleterious oxidative activity. Compared to Hp, hemopexin binds to free heme. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen).