hexokinase
Sign in to saveAlso known as hexokinase (phosphorylating), ATP:D-hexose 6-phosphotransferase, hexokinase type IV glucokinase, ATP-dependent hexokinase, glucose ATP phosphotransferase
A hexokinase is an enzyme that irreversibly phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate for hexokinases, and glucose-6-phosphate is the most important product. Hexokinase possesses the ability to transfer an inorganic phosphate group from ATP to a substrate.
Key facts
- Protein.OMIM
- 142570
- Protein.Name
- hexokinase 3 (white cell)
- Protein.caption
- Hexokinase 1, homodimer, Human
- Protein.image
- 1hkc.jpg
- Protein.width
- 270
- Protein.HGNCid
- 4925
- Protein.Symbol
- HK3
- Protein.EntrezGene
- 3101
- Protein.RefSeq
- NM_002115
- Protein.UniProt
- P52789
- Protein.Chromosome
- 2
- Protein.Arm
- p
- Protein.Band
- 35.2
- Protein family.Symbol
- Hexokinase_2
- Protein family.Name
- Hexokinase_2
- Protein family.image
- PDB 1bg3 EBI.jpg
- Protein family.caption
- rat brain hexokinase type i complex with glucose and inhibitor glucose-6-phosphate
- Protein family.Pfam
- PF03727
via Wikipedia infobox
Research
13,273 papers- HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection.Autophagy · 2015
- [Hexokinase].Nihon rinsho. Japanese journal of clinical medicine · 2002
- Hexokinase domain-containing protein-1 in metabolic diseases and beyond.Trends in endocrinology and metabolism: TEM · 2022
- Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis.Cell metabolism · 2021
- Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters.International journal of molecular sciences · 2021
via PubMed
Wikidata facts
Show 2 more facts
- EC enzyme number
- 2.7.1.1
- Commons category
- Hexokinase
Sources (2)
via Wikidata · CC0
~7 min read
Article
12 sectionsContents
- Variation
- Reaction
- Consequences of hexose phosphorylation
- Size of different isoforms
- Types of mammalian hexokinase
- Hexokinases I, II, and III
- Hexokinase IV ("glucokinase")
- In glycolysis
- Association with mitochondria
- Deficiency
- See also
- References
A hexokinase is an enzyme that irreversibly phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate for hexokinases, and glucose-6-phosphate is the most important product. Hexokinase possesses the ability to transfer an inorganic phosphate group from ATP to a substrate.
Hexokinases should not be confused with glucokinase, which is a specific hexokinase found in the liver. All hexokinases are capable of phosphorylating several hexoses but hexokinase IV(D) is often misleadingly called glucokinase, though it is no more specific for glucose than the other mammalian isoenzymes.