FOXK1
Sign in to saveAlso known as FOXK1L, forkhead box K1
Forkhead box protein K1 is a transcription factor of the forkhead box family that in humans is encoded by the FOXK1 gene.
Gene data
FOXK1- Name
- forkhead box K1
- Type
- protein-coding
- Position
- 4,682,240–4,771,442 (+)
- Aliases
- FOXK1L
- Ensembl
- ENSG00000164916
- RefSeq RNA
- NM_001037165.2
- RefSeq protein
- NP_001032242.1
Enables 14-3-3 protein binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular glucose homeostasis; negative regulation of autophagy; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
forkhead box K1
- Symbol
- FOXK1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:4,682,240-4,771,442
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein FOXK1 PDB 2a3s.png
Show 8 more facts
- HomoloGene ID
- 82414
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/221937
- genomic end
- 4771442
- genomic start
- 4682295
- chromosome
- human chromosome 7
- cytogenetic location
- 7p22.1
- expressed in
- thalamus
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Forkhead box protein K1 is a transcription factor of the forkhead box family that in humans is encoded by the FOXK1 gene.
During starvation, in type 2 diabetes, in rapidly dividing cells during embryogenesis, in tumors (Warburg effect) and during T cell proliferation, aerobic glycolysis is induced to produce the building block to sustain growth. FOXK1 is one of the transcription factors managing the passage from the normal cellular respiration (complete glucose oxidation) to generating ATP and intermediaries for many other biochemical pathways.
Excerpted from Wikipedia’s “FOXK1” article, available under the CC BY-SA 4.0 licence.