File:Hydrochlorothiazide.svg · Wikimedia Commons · See Wikimedia Commons
hydrochlorothiazide
Sign in to saveAlso known as hydrochlorthiazide, chlorsulfonamidodihydrobenzothiadiazine dioxide, 6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide, 3,4-dihydrochlorothiazide
Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in hypercalciuria. Hydrochlorothiazide is taken by mouth and may be combined with other blood pressure medications as a single pill to increase effectiveness. Hydrochlorothiazide is a thiazide medication which inhibits reabsorption of sodium and chloride ions from the distal convoluted tubules of the kidneys, causing a na
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 443860485
- Drug.image
- Hydrochlorothiazide.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Hydrochlorothiazide-from-xtal-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Hydrodiuril, others
- Drug.MedlinePlus
- a682571
- Drug.DailyMedID
- Hydrochlorothiazide
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- C03
- Drug.ATC_suffix
- AA03
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.bioavailability
- Variable (~70% on average)
via Wikipedia infobox
Chemical data
- Formula
- C7H8ClN3O4S2
- Molecular weight
- 297.7 g/mol
- IUPAC name
- 6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
- SMILES
- C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
- InChIKey
- JZUFKLXOESDKRF-UHFFFAOYSA-N
- XLogP
- -0.1
- Polar surface area
- 135 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 296.964
Show 7 more facts
- chemical formula
- C₇H₈ClN₃O₄S₂
- canonical SMILES
- C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
- World Health Organisation international non-proprietary name
- hydrochlorothiazide
- Commons category
- Hydrochlorothiazide
- defined daily dose
- 25
- melting point
- 269
- stylized name
- hydroCHLOROthiazide
Sources (8)
via Wikidata · CC0
~9 min read
Article
7 sectionsContents
- Mechanism of action
- Medical uses
- Adverse effects
- Society and culture
- Brand names
- Sport
- References
Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in hypercalciuria. Hydrochlorothiazide is taken by mouth and may be combined with other blood pressure medications as a single pill to increase effectiveness. Hydrochlorothiazide is a thiazide medication which inhibits reabsorption of sodium and chloride ions from the distal convoluted tubules of the kidneys, causing a natriuresis. This initially increases urine volume and lowers blood volume. It is believed to reduce peripheral vascular resistance.
Potential side effects include poor kidney function, electrolyte imbalances, including low blood potassium, and, less commonly, low blood sodium, gout, high blood sugar, and feeling lightheaded with standing.