idoxuridine

Also known as Dendrid, 1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil, 1-beta-D-2'-Deoxyribofuranosyl-5-iodouracil, 5-Iododeoxyuridine, Idoxuridinum, Iododeoxyridine, 5-Iodouracil deoxyriboside, Idoxuridina

Idoxuridine is an anti-herpesvirus antiviral drug.

Research

2,954 papers

Therapeutics. XIV. Herpes simplex virus infections and idoxuridine.The British journal of dermatology · 1971
TO-DAY'S DRUGS. IDOXURIDINE.British medical journal · 1964
HYDROLYSIS OF IDOXURIDINE.Journal of pharmaceutical sciences · 1964
Ineffectiveness of topical idoxuridine in dimethyl sulfoxide for therapy for genital herpes.JAMA · 1982
IDOXURIDINE--A PRELIMINARY REPORT.Journal of pharmaceutical sciences · 1964

via PubMed

Wikidata facts

Mass: 353.971

Show 5 more facts

chemical formula: C₉H₁₁IN₂O₅
isomeric SMILES: C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)I)CO)O
canonical SMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)I)CO)O
World Health Organisation international non-proprietary name: idoxuridine
Commons category: Idoxuridine

Sources (5)

via Wikidata · CC0

~2 min read

Article

7 sections

Contents

Clinical use
Side effects
Formulations and dosage
Synthesis
See also
References
Further reading

Idoxuridine is an anti-herpesvirus antiviral drug.

It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing. It is used only topically due to cardiotoxicity. It was synthesized by William Prusoff in the late 1950s. Initially developed as an anticancer drug, idoxuridine became the first antiviral agent in 1962.