Structure via PubChem · Public domain (PubChem)
cidofovir
Sign in to saveAlso known as GS-0504, 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine, CDV, (S)-1-[3-Hydroxy-2-(phosphonylmethoxy)propyl]cytosine, [(S)-2-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-1-hydroxymethyl-ethoxymethyl]-phosphonic acid, (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine, (S)-(3-(4-amino-2-Oxopyrimidin-1(2H)-yl)-1-hydroxypropan-2-yloxy)methylphosphonic acid, (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine
Cidofovir, brand name Vistide, is a topical or injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis (an infection of the retina of the eye) in people with AIDS.
In the Vinony graph
Vinony's link graph records 100 inbound references to cidofovir, and connects out to human papillomavirus infection, Herpesviridae and uveitis.
Vinony files it under Amines, Anti-herpes virus drugs and ECHA InfoCard ID from Wikidata.
Vinony links it to 22 Wikipedia language editions.
Key facts
- Drug.verifiedrevid
- 477165826
- Drug.IUPAC_name
- ({[(S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
- Drug.image
- Cidofovir.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 225
- Drug.tradename
- Vistide
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- Intravenous
- Drug.ATC_prefix
- J05
- Drug.ATC_suffix
- AB12
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.bioavailability
- complete
- Drug.protein_bound
- <6%
- Drug.elimination_half life
- 2.6 hours (active metabolites: 15–65 hours)
- Drug.excretion
- renal The above pharmacokinetic parameters are measured for cidofovir used in conjunction with probenecid.
via Wikipedia infobox
Chemical data
- Formula
- C8H14N3O6P
- Molecular weight
- 279.19 g/mol
- IUPAC name
- [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid
- SMILES
- C1=CN(C(=O)N=C1N)C[C@@H](CO)OCP(=O)(O)O
- InChIKey
- VWFCHDSQECPREK-LURJTMIESA-N
- XLogP
- -3.6
- Polar surface area
- 146 Ų
- H-bond donors
- 4
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
2,555 papers- Cidofovir.Drugs · 1996
- Cidofovir.Archives of ophthalmology (Chicago, Ill. : 1960) · 1997
- Cidofovir in the Management of Non-Genital Warts: A Review.Journal of drugs in dermatology : JDD · 2023
- Cidofovir.The AIDS reader · 1999
- Intralesional cidofovir vs. bevacizumab for recurrent respiratory papillomatosis: a systematic review and indirect meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
via PubMed
Wikidata facts
- Mass
- 279.062
Show 5 more facts
- chemical formula
- C₈H₁₄N₃O₆P
- defined daily dose
- 25
- isomeric SMILES
- C1=CN(C(=O)N=C1N)C[C@@H](CO)OCP(=O)(O)O
- canonical SMILES
- C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O
- Commons category
- Cidofovir
Sources (9)
via Wikidata · CC0
~3 min read
Encyclopedic overview
12 sectionsContents
- Medical use
- DNA virus
- Other
- Administration
- Side effects
- Contraindications
- Interactions
- Mechanism of action
- History
- Synthesis
- See also
- References
{{Infobox drug | verifiedrevid = 477165826 | IUPAC_name = ({[(S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid | image = Cidofovir.svg | image_class = skin-invert-image | width = 225
| tradename = Vistide | Drugs.com = | pregnancy_AU = D | routes_of_administration = Intravenous | ATC_prefix = J05 | ATC_suffix = AB12 | ATC_supplemental =
Excerpted from Wikipedia’s “cidofovir” article, available under the CC BY-SA 4.0 licence.