Structure via PubChem · Public domain (PubChem)
famciclovir
Sign in to saveAlso known as FAM810, Famvir, Acetic acid 2-acetoxymethyl-4-(2-amino-purin-9-yl)-butyl ester, 9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine, BRL-42810, 2-(2-(2-amino-9H-Purin-9-yl)ethyl)-1,3-propanediol diacetate, FCV
Famciclovir is a guanosine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis).
Chemical data
- Formula
- C14H19N5O4
- Molecular weight
- 321.33 g/mol
- IUPAC name
- [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate
- SMILES
- CC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C
- InChIKey
- GGXKWVWZWMLJEH-UHFFFAOYSA-N
- XLogP
- 0
- Polar surface area
- 122 Ų
- H-bond donors
- 1
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Research
949 papers- Famciclovir/penciclovir.Advances in experimental medicine and biology · 1999
- Famciclovir: review of clinical efficacy and safety.Antiviral research · 1996
- Famciclovir: a focus on efficacy and safety.Expert opinion on drug safety · 2010
- Recommendations for the management of herpes zoster.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2007
- Famciclovir. A review of its pharmacological properties and therapeutic efficacy in herpesvirus infections.Drugs · 1995
via PubMed
Wikidata facts
- Subclass of
- nucleoside analogue
- Mass
- 321.143704
- Has use
- medication
Show 9 more facts
- canonical SMILES
- CC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C
- chemical formula
- C₁₄H₁₉N₅O₄
- medical condition treated
- genital herpes
- World Health Organisation international non-proprietary name
- famciclovir
- defined daily dose
- 0.75
- subject has role
- antiviral drug
- Commons category
- Famciclovir
- melting point
- 103
- legal status (medicine)
- prescription drug
Sources (7)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Medical uses
- Adverse effects
- Herpes
- Early treatment
- History
- References
Famciclovir is a guanosine analogue antiviral drug used for the treatment of various herpesvirus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis).
Famciclovir was patented in 1983 and approved for medical use in 1994. In 2007, the United States Food and Drug Administration approved the first generic version of famciclovir. Generic tablets are manufactured by TEVA Pharmaceuticals and Mylan Pharmaceuticals.
Excerpted from Wikipedia’s “famciclovir” article, available under the CC BY-SA 4.0 licence.