Structure via PubChem · Public domain (PubChem)
sorivudine
Sign in to saveSorivudine (INN), is a nucleoside analogue antiviral drug, marketed under trade names such as Usevir (Nippon Shoji, Eisai) and Brovavir (BMS). It is used for the treatment of varicella zoster virus infections.
Chemical data
- Formula
- C11H13BrN2O6
- Molecular weight
- 349.13 g/mol
- IUPAC name
- 5-[(E)-2-bromoethenyl]-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- SMILES
- C1=C(C(=O)NC(=O)N1[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O)/C=C/Br
- InChIKey
- GCQYYIHYQMVWLT-HQNLTJAPSA-N
- XLogP
- -0.9
- Polar surface area
- 119 Ų
- H-bond donors
- 4
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
119 papers- Sorivudine: a promising drug for the treatment of varicella-zoster virus infection.Neurology · 1995
- Sorivudine: a potent inhibitor of varicella zoster virus replication.Advances in experimental medicine and biology · 1996
- [Lethal drug interactions of the new antiviral, sorivudine, with anticancer prodrugs of 5-fluorouracil].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan · 1997
- [Molecular toxicological mechanism of the lethal interactions of the new antiviral drug, sorivudine, with 5-fluorouracil prodrugs and genetic deficiency of dihydropyrimidine dehydrogenase].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan · 2002
- Sorivudine versus acyclovir for treatment of dermatomal herpes zoster in human immunodeficiency virus-infected patients: results from a randomized, controlled clinical trial. Collaborative Antiviral Study Group/AIDS Clinical Trials Group, Herpes Zoster Study Group.Antimicrobial agents and chemotherapy · 1998
via PubMed
Wikidata facts
- Mass
- 347.99569823600007
Show 4 more facts
- chemical formula
- C₁₁H₁₃BrN₂O₆
- isomeric SMILES
- c1c(c(=O)[nH]c(=O)n1[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O)/C=C/Br
- Commons category
- Sorivudine
- canonical SMILES
- O=c1[nH]c(=O)n(C2OC(CO)C(O)C2O)cc1C=CBr
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Pharmacology
- Feature
- Mechanism of action
- Microbiology
- Interactions
- References
Sorivudine (INN), is a nucleoside analogue antiviral drug, marketed under trade names such as Usevir (Nippon Shoji, Eisai) and Brovavir (BMS). It is used for the treatment of varicella zoster virus infections.
==Pharmacology== ===Feature=== Treatment of herpes drug acyclovir was (Zovirax, Activir) from VZV strong activity of the virus. Undergoes gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted in urine.
Excerpted from Wikipedia’s “sorivudine” article, available under the CC BY-SA 4.0 licence.
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