ABCC2

Name

ATP binding cassette subfamily C member 2

Type

protein-coding

Aliases

ABC30, CMOAT, DJS, MRP2, cMRP

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

ATP binding cassette subfamily C member 2

Symbol

ABCC2

Biotype

Protein coding

Organism

Homo sapiens

Location

10:99,782,640-99,853,670

Strand

Forward (+)

Assembly

GRCh38

• ABCC2 induces metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux in gastric cancer.Clinical and translational medicine · 2024
• ABCC2/Abcc2: a multispecific transporter with dominant excretory functions.Drug metabolism reviews · 2010
• The ABCC2 c.-24C>T polymorphism increases the risk of resistance to antiepileptic drugs: A meta-analysis.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2017
• ABCC2/Abcc2 transport property in different species and its modulation by heterogeneous factors.Drug metabolism and pharmacokinetics · 2008
• The apical conjugate efflux pump ABCC2 (MRP2).Pflugers Archiv : European journal of physiology · 2007

via PubMed

Wikidata facts

via Wikidata · CC0