IFT20
Sign in to saveAlso known as intraflagellar transport 20
Intraflagellar transport protein 20 homolog is a protein that in humans is encoded by the IFT20 gene. The gene is composed of 6 exons and is located on human chromosome 17p11.1. This gene is expressed in human brain, lung, kidney and pancreas, and lower expression were also detected in human placenta, liver, thymus, prostate and testis.
In the Vinony graph
Within Vinony's link graph, IFT20 is referenced by 4 other articles, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 17.
Its subject is documented across 6 Wikipedia language editions.
Gene data
IFT20- Name
- intraflagellar transport 20
- Type
- protein-coding
- Position
- 28,328,319–28,335,489 (−)
- Ensembl
- ENSG00000109083
- RefSeq RNA
- NM_001267774.2, NM_001267775.2, NM_001267776.2, NM_001267777.2, NM_001267778.2
- RefSeq protein
- NP_001254703.1, NP_001254704.1, NP_001254705.1, NP_001254706.1, NP_001254707.1
This gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signalling components (Finetti et al., PubMed: 19855387). This gene is part of a complex set of sense-antisense loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14.[provided by RefSeq, Jun 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
intraflagellar transport 20
- Symbol
- IFT20
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:28,328,319-28,335,489
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 49559
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/90410
- chromosome
- human chromosome 17
- genomic start
- 26655352
- genomic end
- 26662515
- cytogenetic location
- 17q11.2
- expressed in
- periodontal fiber
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Intraflagellar transport protein 20 homolog is a protein that in humans is encoded by the IFT20 gene. The gene is composed of 6 exons and is located on human chromosome 17p11.1. This gene is expressed in human brain, lung, kidney and pancreas, and lower expression were also detected in human placenta, liver, thymus, prostate and testis.
Intraflagellar transport (IFT), in which molecular motors and IFT particle proteins participate, is very important in assembling and maintaining many cilia/flagella, such as the motile cilia that drive the swimming of cells and embryos, the nodal cilia that generate left-right asymmetry in vertebrate embryos, and the sensory cilia that detect sensory stimuli in some animals. IFT20 subunit of the particle is localized to the Golgi complex in addition to the basal body and cilia where all previous IFT particle proteins had been found. In living cells, fluorescently tagged IFT20 is highly dynamic and moves between the Golgi complex and the cilium as well as along ciliary microtubules. IFT20 has been shown to interact with SPEF2 in the testis, and plays a role in sperm motility.
Excerpted from Wikipedia’s “IFT20” article, available under the CC BY-SA 4.0 licence.