IFT20

Also known as intraflagellar transport 20

Intraflagellar transport protein 20 homolog is a protein that in humans is encoded by the IFT20 gene. The gene is composed of 6 exons and is located on human chromosome 17p11.1. This gene is expressed in human brain, lung, kidney and pancreas, and lower expression were also detected in human placenta, liver, thymus, prostate and testis.

Gene data

IFT20

Name: intraflagellar transport 20
Type: protein-coding
Position: 28,328,319–28,335,489 (−)
Ensembl: ENSG00000109083
RefSeq RNA: NM_001267774.2, NM_001267775.2, NM_001267776.2, NM_001267777.2, NM_001267778.2
RefSeq protein: NP_001254703.1, NP_001254704.1, NP_001254705.1, NP_001254706.1, NP_001254707.1

This gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signalling components (Finetti et al., PubMed: 19855387). This gene is part of a complex set of sense-antisense loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14.[provided by RefSeq, Jun 2012].

Gene Ontology

Biological process

spermatogenesis spermatogenesis protein localization to Golgi apparatus intraciliary anterograde transport positive regulation of cilium assembly cilium assembly cilium assembly cilium assembly

Molecular function

opsin binding protein binding small GTPase binding

Cellular component

Golgi membrane acrosomal vesicle acrosomal vesicle photoreceptor outer segment manchette manchette cytoplasm cytoplasm

Pathways

Organelle biogenesis and maintenance Organelle biogenesis and maintenance Cilium Assembly Cilium Assembly Intraflagellar transport Intraflagellar transport Assembly of the 9+0 primary cilium Assembly of the 9+0 primary cilium Ciliary landscape Genes related to primary cilium development (based on CRISPR)

via MyGene.info

Gene · Ensembl

intraflagellar transport 20

Symbol: IFT20
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:28,328,319-28,335,489
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 49559
exact match: identifiers.org/ncbigene/90410
genomic start: 26655352
genomic end: 26662515
cytogenetic location: 17q11.2

Sources (4)

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Contents

References
Further reading

Intraflagellar transport (IFT), in which molecular motors and IFT particle proteins participate, is very important in assembling and maintaining many cilia/flagella, such as the motile cilia that drive the swimming of cells and embryos, the nodal cilia that generate left-right asymmetry in vertebrate embryos, and the sensory cilia that detect sensory stimuli in some animals. IFT20 subunit of the particle is localized to the Golgi complex in addition to the basal body and cilia where all previous IFT particle proteins had been found. In living cells, fluorescently tagged IFT20 is highly dynamic and moves between the Golgi complex and the cilium as well as along ciliary microtubules. IFT20 has been shown to interact with SPEF2 in the testis, and plays a role in sperm motility.