IFT81

Also known as CDV-1, CDV-1R, CDV1, CDV1R, DV1, intraflagellar transport 81, SRTD19

Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene. Together with IFT74/72 it forms a core complex to build IFT particles which are required for cilium formation. Additionally, it interacts with basal body components as CEP170 which regulates the disassembly of the cilium.

In the Vinony graph

Within Vinony's link graph, IFT81 is referenced by 3 other articles, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 12.

Its subject is documented across 5 Wikipedia language editions.

Gene data

IFT81

Name: intraflagellar transport 81
Type: protein-coding
Position: 110,124,314–110,218,795 (+)
Aliases: CDV-1, CDV-1R, CDV1, CDV1R, DV1, SRTD19
Ensembl: ENSG00000122970
RefSeq RNA: NM_001143779.2, NM_001347946.2, NM_001347947.2, NM_001347948.2, NM_014055.4
RefSeq protein: NP_001137251.1, NP_001334875.1, NP_001334876.1, NP_001334877.1, NP_054774.2

The protein encoded by this gene, together with IFT74, forms a tubulin-binding module of intraflagellar transport complex B. This module is involved in transport of tubulin within the cilium, and the encoded protein is required for ciliogenesis. Mutations in this gene are a cause of short-rib polydactyly syndromes. [provided by RefSeq, Dec 2016].