Structure via PubChem · Public domain (PubChem)
indapamide
Sign in to saveAlso known as Hypen SR®, Lozol®
Indapamide is a thiazide-like diuretic drug used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are available. The thiazide-like diuretics (indapamide and chlorthalidone) reduce risk of major cardiovascular events and heart failure in hypertensive patients compared with hydrochlorothiazide with a comparable incidence of adverse events. Both thiazide diuretics and thiazide-like diuretics are effective in reducing risk of stroke. Both drug classes appear to have comparable rates of adverse ef
Chemical data
- Formula
- C16H16ClN3O3S
- Molecular weight
- 365.8 g/mol
- IUPAC name
- 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
- SMILES
- CC1CC2=CC=CC=C2N1NC(=O)C3=CC(=C(C=C3)Cl)S(=O)(=O)N
- InChIKey
- NDDAHWYSQHTHNT-UHFFFAOYSA-N
- XLogP
- 2.9
- Polar surface area
- 101 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
1,577 papers- Indapamide: a review.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 1983
- Not So Innocent Indapamide.Journal of Ayub Medical College, Abbottabad : JAMC · 2023
- Indapamide sustained release: a review of its use in the treatment of hypertension.Drugs · 2006
- Perindopril 2mg/indapamide 0.625mg. Fixed low-dose combination.Drugs · 1999
- The effect of indapamide vs. bendroflumethiazide for primary hypertension: a systematic review.British journal of clinical pharmacology · 2019
via PubMed
Wikidata facts
- Mass
- 365.06009
Show 4 more facts
- chemical formula
- C₁₆H₁₆ClN₃O₃S
- canonical SMILES
- CC1CC2=CC=CC=C2N1NC(=O)C3=CC(=C(C=C3)Cl)S(=O)(=O)N
- defined daily dose
- 2.5
- Commons category
- Indapamide
Sources (8)
via Wikidata · CC0
~4 min read
Article
8 sectionsContents
- Medical uses
- Contraindications
- Adverse effects
- Interactions
- Overdose
- See also
- References
- External links
Indapamide is a thiazide-like diuretic drug used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are available. The thiazide-like diuretics (indapamide and chlorthalidone) reduce risk of major cardiovascular events and heart failure in hypertensive patients compared with hydrochlorothiazide with a comparable incidence of adverse events. Both thiazide diuretics and thiazide-like diuretics are effective in reducing risk of stroke. Both drug classes appear to have comparable rates of adverse effects as other antihypertensives such as angiotensin II receptor blockers and dihydropyridine calcium channel blockers and lesser prevalence of side-effects when compared to ACE-inhibitors and non-dihydropyridine calcium channel blockers.
It was patented in 1968 and approved for medical use in 1977. It is on the World Health Organization's List of Essential Medicines.