IQGAP1

Also known as HUMORFA01, SAR1, p195, IQ motif containing GTPase activating protein 1

Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene. IQGAP1 is a scaffold protein involved in regulating various cellular processes ranging from organization of the actin cytoskeleton, transcription, and cellular adhesion to regulating the cell cycle.

Gene data

IQGAP1

Name: IQ motif containing GTPase activating protein 1
Type: protein-coding
Aliases: HUMORFA01, SAR1, p195

This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

IQ motif containing GTPase activating protein 1

Symbol: IQGAP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:90,388,207-90,502,239
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein IQGAP1 PDB 1x0h.png

Show 5 more facts

HomoloGene ID: 74514
exact match: identifiers.org/ncbigene/8826
genomic end: 90502239
genomic start: 90388242
cytogenetic location: 15q26.1

Sources (6)

via Wikidata · CC0

~13 min read

Article

15 sections

Contents

History
Expression
Domains
Related Proteins
Function
Interactions
Function as a Scaffold
Key pathways
ERK MAPK
Cytoskeletal control (actin dynamics)
Adhesion
Transcription
Clinical significance
References
Further reading

==History== IQGAP1 was discovered in 1994. Its name stems from the fact that its RasGAP-related domain (GRD) has sequence homology to the Sar1 GTPase. It was hypothesized that IQGAP1 would act as a GTPase activating protein (GAP) protein, promoting the switch of ras GTPases from the active GTP to GDP-bound forms. However, despite the homology of IQGAP’s GAP domain to sar1 and the fact that IQGAP1 binds Rho GTPases Rac1 and Cdc42, IQGAP does not actually have GAP function. Instead, it binds the active (GTP-bound) forms of RAC1 and CDC42 with higher affinity than GDP-bound forms, and stabilizes the active form in vivo.