ISG20

Also known as CD25, HEM45, interferon stimulated exonuclease gene 20kDa, interferon stimulated exonuclease gene 20

Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene. It belongs to the ISG family of proteins, which are typically stimulated by type I interferon as a response to viral infection.

Gene data

ISG20

Name: interferon stimulated exonuclease gene 20
Type: protein-coding
Position: 88,635,618–88,656,483 (+)
Aliases: CD25, HEM45
Ensembl: ENSG00000172183
RefSeq RNA: NM_001303233.2, NM_001303234.2, NM_001303235.2, NM_001303236.2, NM_001303237.2
RefSeq protein: NP_001290162.1, NP_001290163.1, NP_001290164.1, NP_001290165.1, NP_001290166.1

Enables 3'-5' exonuclease activity and RNA binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Located in cytoplasm and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

DNA metabolic process DNA catabolic process

~2 min read

Article

6 sections

Contents

Discovery
Structure
Function
Clinical significance
References
Further reading

==Discovery== ISG20 was discovered in 1997 at the Institute for Molecular Genetics (IGMM) within the University of Montpellier. The new protein was discovered through differential display in IFNα/β treated human cells.