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isotonitazene
Sign in to saveAlso known as 2-[2-(4-isopropoxybenzyl)-5-nitro-1H-benzimidazol-1-yl]-N,N-diethylethanamine
Isotonitazene is a synthetic opioid analgesic drug from the nitazene class and structural homolog of etonitazene, which has been sold as a designer drug. It has only around half the potency of etonitazene in animal studies, but it is likely even less potent in humans as was seen with etonitazene (1000 times as potent as morphine in animal models yet only 60 times as potent in humans). Isotonitazene (obtained from an online vendor) was fully characterized in November 2019 in a paper where the authors performed a full analytical structure elucidation in addition to determination of the potency a
Chemical data
- Formula
- C23H30N4O3
- Molecular weight
- 410.5 g/mol
- IUPAC name
- N,N-diethyl-2-[5-nitro-2-[(4-propan-2-yloxyphenyl)methyl]benzimidazol-1-yl]ethanamine
- SMILES
- CCN(CC)CCN1C2=C(C=C(C=C2)[N+](=O)[O-])N=C1CC3=CC=C(C=C3)OC(C)C
- InChIKey
- OIOQREYBGDAYGT-UHFFFAOYSA-N
- XLogP
- 4.7
- Polar surface area
- 76.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 410.23179081999996
Show 3 more facts
- canonical SMILES
- CCN(CC)CCN1C2=C(C=C(C=C2)[N+](=O)[O-])N=C1CC3=CC=C(C=C3)OC(C)C
- Commons category
- Isotonitazene
- chemical formula
- C₂₃H₃₀N₄O₃
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Side effects
- Legal status
- See also
- References
Isotonitazene is a synthetic opioid analgesic drug from the nitazene class and structural homolog of etonitazene, which has been sold as a designer drug. It has only around half the potency of etonitazene in animal studies, but it is likely even less potent in humans as was seen with etonitazene (1000 times as potent as morphine in animal models yet only 60 times as potent in humans). Isotonitazene (obtained from an online vendor) was fully characterized in November 2019 in a paper where the authors performed a full analytical structure elucidation in addition to determination of the potency at the μ-opioid receptor using a biological functional assay in vitro. While isotonitazene was not compared directly to morphine in this assay, it was found to be around 2.5 times more potent than hydromorphone and slightly more potent than fentanyl.
== Side effects ==
Excerpted from Wikipedia’s “isotonitazene” article, available under the CC BY-SA 4.0 licence.