KDM6B

Also known as JMJD3, lysine demethylase 6B, NEDCFSA

Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B (JMJD3) gene.

Gene data

KDM6B

Name: lysine demethylase 6B
Type: protein-coding
Position: 7,834,193–7,854,796 (+)
Aliases: JMJD3, NEDCFSA, NEDSST
Ensembl: ENSG00000132510
RefSeq RNA: NM_001080424.2, NM_001348716.2
RefSeq protein: NP_001073893.1, NP_001335645.1

The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017].

Gene Ontology

Biological process

inflammatory response to antigenic stimulus

Article

9 sections

Contents

Regulation during differentiation
Small molecule inhibition
Role in pathology
Clinical picture
Epidemiology
Related conditions
Ongoing research
References
Further reading

Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B (JMJD3) gene.

== Regulation during differentiation == KDM6B was found to be expressional increased during cardiac and endothelial differentiation of murine embryonic stem cells.