LARP1
Sign in to saveAlso known as LARP, La ribonucleoprotein domain family member 1, La ribonucleoprotein 1, translational regulator, Lar1, Lhp1
La-related protein 1 (LARP1) is a 150 kDa protein that in humans is encoded by the LARP1 gene. LARP1 is a novel target of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, a circuitry often hyperactivated in cancer which regulates cell growth and proliferation primarily through the regulation of protein synthesis.
In the Vinony graph
Within Vinony's link graph, LARP1 is referenced by 3 other articles, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 5.
Its subject is documented across 6 Wikipedia language editions.
Gene data
LARP1- Name
- La ribonucleoprotein 1, translational regulator
- Type
- protein-coding
- Position
- 154,682,986–154,817,607 (+)
- Aliases
- LARP, Lar1, Lhp1
- Ensembl
- ENSG00000155506
- RefSeq RNA
- NM_001367713.1, NM_001367714.1, NM_001367715.1, NM_001367716.1, NM_001367717.1
- RefSeq protein
- NP_001354642.1, NP_001354643.1, NP_001354644.1, NP_001354645.1, NP_001354646.1
Enables eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Involved in several processes, including TORC1 signaling; cellular response to rapamycin; and posttranscriptional regulation of gene expression. Located in cytoplasmic stress granule. Colocalizes with TORC1 complex and polysomal ribosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
La ribonucleoprotein 1, translational regulator
- Symbol
- LARP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:154,682,986-154,817,607
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 9089
- exact match
- identifiers.org/ncbigene/23367
- found in taxon
- Homo sapiens
- genomic end
- 154817605
- genomic start
- 154682986
- chromosome
- human chromosome 5
- cytogenetic location
- 5q33.2
- expressed in
- renal medulla
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
La-related protein 1 (LARP1) is a 150 kDa protein that in humans is encoded by the LARP1 gene. LARP1 is a novel target of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, a circuitry often hyperactivated in cancer which regulates cell growth and proliferation primarily through the regulation of protein synthesis.
== Function ==
Excerpted from Wikipedia’s “LARP1” article, available under the CC BY-SA 4.0 licence.