MLST8
Sign in to saveAlso known as GBL, GbetaL, LST8, POP3, WAT1, MTOR associated protein, LST8 homolog
Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene. It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals. It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.
In the Vinony graph
Within Vinony's link graph, MLST8 is referenced by 7 other articles, and connects out to PubMed, human chromosome 16 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 16.
Its subject is documented across 7 Wikipedia language editions.
Gene data
MLST8- Name
- MTOR associated protein MLST8
- Type
- protein-coding
- Position
- 2,204,248–2,209,453 (+)
- Aliases
- GBL, GbetaL, LST8, POP3, WAT1
- Ensembl
- ENSG00000167965
- RefSeq RNA
- NM_001199173.3, NM_001199174.3, NM_001199175.3, NM_001352057.2, NM_001352059.2
- RefSeq protein
- NP_001186102.1, NP_001186103.1, NP_001186104.1, NP_001338986.1, NP_001338988.1
Enables protein serine/threonine kinase activator activity. Involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
MTOR associated protein MLST8
- Symbol
- MLST8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:2,204,248-2,209,453
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 6833
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/64223
- chromosome
- human chromosome 16
- genomic start
- 2254249
- genomic end
- 2209453
- cytogenetic location
- 16p13.3
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene. It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals. It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.
==References==
Excerpted from Wikipedia’s “MLST8” article, available under the CC BY-SA 4.0 licence.