LRPPRC

Also known as CLONE-23970, GP130, LRP130, LSFC, leucine rich pentatricopeptide repeat containing, MC4DN5

Leucine-rich PPR motif-containing protein, mitochondrial is a protein that in humans is encoded by the LRPPRC gene. Transcripts ranging in size from 4.8 to 7.0 kb which result from alternative polyadenylation have been reported for this gene.

Gene data

LRPPRC

Name: leucine rich pentatricopeptide repeat containing
Type: protein-coding
Aliases: CLONE-23970, GP130, LRP130, LSFC, MC4DN5

This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012].

via MyGene.info

Gene · Ensembl

leucine rich pentatricopeptide repeat containing

Symbol: LRPPRC
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:43,886,224-43,996,226
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 32695
exact match: identifiers.org/ncbigene/10128
genomic end: 43996226
genomic start: 43886224
cytogenetic location: 2p21

Sources (4)

via Wikidata · CC0

~1 min read

Article

5 sections

Contents

Function
Clinical significance
References
Further reading
External links

==Function== This gene encodes a protein that is leucine-rich and is thought to play a role in regulating the interaction of the cytoskeleton with a variety of cellular processes.