levomethadyl acetate
Sign in to saveAlso known as Levacetilmetadol, Levacetylmethadolum, levo-α-acetylmethadol, Levo-methadyl acetate, (1S,4S)-4-(dimethylamino)-1-ethyl-2,2-diphenylpentyl acetate, Orlaam®, (1S,4S)-4-(dimethylamino)-1-Ethyl-2,2-diphenylpentyl acetate
Levacetylmethadol (INN), levomethadyl acetate (USAN), OrLAAM (trade name) or levo-α-acetylmethadol (LAAM) is a synthetic opioid similar in structure to methadone. It has a long duration of action due to its active metabolites.
Research
422 papers- A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence.The New England journal of medicine · 2000
- Torsades de pointes associated with high dose levomethadyl acetate (ORLAAM).Journal of addictive diseases · 2001
- Induction with levomethadyl acetate: safety and efficacy.Archives of general psychiatry · 1998
- Levomethadyl acetate. Prolonged duration of opioid effects, including cross tolerance to heroin, in man.JAMA · 1973
- Dose-related efficacy of levomethadyl acetate for treatment of opioid dependence. A randomized clinical trial.JAMA · 1997
via PubMed
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Encyclopedic overview
11 sectionsContents
- Medical uses
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- History
- Society and culture
- Legal status
- References
- Further reading
- External links
Levacetylmethadol (INN), levomethadyl acetate (USAN), OrLAAM (trade name) or levo-α-acetylmethadol (LAAM) is a synthetic opioid similar in structure to methadone. It has a long duration of action due to its active metabolites.
==Medical uses== LAAM is indicated as a second-line treatment for the treatment and management of opioid dependence if patients fail to respond to drugs like methadone or buprenorphine.
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