LMO1

Also known as RBTN1, RHOM1, TTG1, LIM domain only 1

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.

Gene data

LMO1

Name: LIM domain only 1
Type: protein-coding
Position: 8,224,309–8,268,752 (−)
Aliases: RBTN1, RHOM1, TTG1
Ensembl: ENSG00000166407
RefSeq RNA: NM_001270428.2, NM_002315.3, NR_073006.2, XM_006718228.4, XM_011520098.3
RefSeq protein: NP_001257357.1, NP_002306.1, XP_006718291.1, XP_011518400.1, XP_011518401.1

This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012].

Gene Ontology

Biological process

positive regulation of transcription by RNA polymerase II

Article

3 sections

Contents

Interactions
References
Further reading

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.

LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.