LMO1

Also known as RBTN1, RHOM1, TTG1, LIM domain only 1

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.

Gene data

LMO1

Name: LIM domain only 1
Type: protein-coding
Position: 8,224,309–8,268,752 (−)
Aliases: RBTN1, RHOM1, TTG1
Ensembl: ENSG00000166407
RefSeq RNA: NM_001270428.2, NM_002315.3, NR_073006.2, XM_006718228.4, XM_011520098.3
RefSeq protein: NP_001257357.1, NP_002306.1, XP_006718291.1, XP_011518400.1, XP_011518401.1

This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012].

Gene Ontology

Biological process

positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Molecular function

transcription coactivator activity protein binding

Cellular component

nucleus nucleus nucleus nucleoplasm

Pathways

Generic Transcription Pathway RNA Polymerase II Transcription Gene expression (Transcription)Transcriptional regulation by RUNX1 RUNX1 regulates transcription of genes involved in differentiation of HSCs

via MyGene.info

Gene · Ensembl

LIM domain only 1

Symbol: LMO1
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:8,224,309-8,268,807
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 48101
exact match: identifiers.org/ncbigene/4004
genomic end: 8290263
genomic start: 8224309
cytogenetic location: 11p15.4

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Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.

LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.