MCUB
Sign in to saveAlso known as EMRE, CCDC109B, Ccdc109b, coiled-coil domain containing 109B, mitochondrial calcium uniporter dominant negative beta subunit, mitochondrial calcium uniporter dominant negative subunit beta
Coiled-coil domain containing 109B (CCDC109B) is a potential calcium uniporter protein found in the membrane of human cells and is encoded by the CCDC109B gene. While CCDC109B is a transmembrane protein it is unclear if it is located within the cell membrane or mitochondrial membrane.
In the Vinony graph
Within Vinony's link graph, MCUB is referenced by 1 other article, and connects out to PubMed, Ensembl genome database project and sequence homology.
It is catalogued under the topic Genes on human chromosome 4.
Its subject is documented across 4 Wikipedia language editions.
Gene data
MCUB- Name
- mitochondrial calcium uniporter dominant negative subunit beta
- Type
- protein-coding
- Position
- 109,560,209–109,688,799 (+)
- Aliases
- CCDC109B
- Ensembl
- ENSG00000005059
- RefSeq RNA
- NM_017918.5, XM_006714246.4, XM_054350319.1
- RefSeq protein
- NP_060388.2, XP_006714309.1, XP_054206294.1
Predicted to enable calcium channel inhibitor activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Located in mitochondrion and nucleoplasm. Is integral component of mitochondrial inner membrane. Part of uniplex complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
mitochondrial calcium uniporter dominant negative subunit beta
- Symbol
- MCUB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:109,560,209-109,688,799
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- exact match
- identifiers.org/ncbigene/55013
- HomoloGene ID
- 23056
- found in taxon
- Homo sapiens
- genomic end
- 109688719
- genomic start
- 109560209
- chromosome
- human chromosome 4
- cytogenetic location
- 4q25
- Commons category
- Ccdc109b
- expressed in
- Achilles tendon
Sources (4)
via Wikidata · CC0
~8 min read
Encyclopedic overview
16 sectionsContents
- Gene information
- Protein information
- Protein domains
- Post-translational modifications
- Phosphorylation sites
- Sumoylation site
- Tertiary structure
- Homology
- Paralog of CCDC109B
- Expression profile
- Role in disease
- Protein-protein interaction
- Transcription factors
- Cellular proteins
- References
- External links
Coiled-coil domain containing 109B (CCDC109B) is a potential calcium uniporter protein found in the membrane of human cells and is encoded by the CCDC109B gene. While CCDC109B is a transmembrane protein it is unclear if it is located within the cell membrane or mitochondrial membrane.
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Excerpted from Wikipedia’s “MCUB” article, available under the CC BY-SA 4.0 licence.