MECR

Also known as CGI-63, FASN2B, NRBF1, mitochondrial trans-2-enoyl-CoA reductase, ETR1, DYTOABG

Trans-2-enoyl-CoA reductase, mitochondrial is an enzyme that in humans is encoded by the MECR gene.

Gene data

MECR

Name: mitochondrial trans-2-enoyl-CoA reductase
Type: protein-coding
Position: 29,192,657–29,230,945 (−)
Aliases: CGI-63, DYTOABG, ETR1, FASN2B, NRBF1, OPA16
Ensembl: ENSG00000116353
RefSeq RNA: NM_001024732.4, NM_001349711.2, NM_001349712.2, NM_001349713.2, NM_001349714.2
RefSeq protein: NP_001019903.3, NP_001336640.1, NP_001336641.1, NP_001336642.1, NP_001336643.1

The protein encoded by this gene is an oxidoreductase that catalyzes the last step in mitochondrial fatty acid synthesis. Defects in this gene are a cause of childhood-onset dystonia and optic atrophy. [provided by RefSeq, Mar 2017].

Gene Ontology

Biological process

fatty acid metabolic process fatty acid metabolic process fatty acid metabolic process intracellular iron ion homeostasis ceramide biosynthetic process

Molecular function

oxidoreductase activity enoyl-[acyl-carrier-protein] reductase (NADPH) activity enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Cellular component

nucleus cytoplasm mitochondrion mitochondrion mitochondrion mitochondrion mitochondrial matrix

Pathways

Fatty acid biosynthesis - Homo sapiens (human)Fatty acid elongation - Homo sapiens (human)Metabolism Metabolism of lipids mitochondrial fatty acid beta-oxidation of saturated fatty acids Mitochondrial Fatty Acid Beta-Oxidation Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Fatty acid metabolism Fatty Acid Biosynthesis Mitochondrial fatty acid synthesis pathway

via MyGene.info

Gene · Ensembl

mitochondrial trans-2-enoyl-CoA reductase

Symbol: MECR
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:29,192,657-29,230,958
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein MECR PDB 1zsy.png

Show 5 more facts

HomoloGene ID: 5362
exact match: identifiers.org/ncbigene/51102
genomic end: 29557454
genomic start: 29192657
cytogenetic location: 1p35.3

Sources (5)

via Wikidata · CC0

~2 min read

Article

6 sections

Contents

Structure
Function
Clinical significance
See also
References
Further reading

Trans-2-enoyl-CoA reductase, mitochondrial is an enzyme that in humans is encoded by the MECR gene.

== Structure == The MECR gene is located on the 1st chromosome, with its specific location being 1p35.3. The gene contains 15 exons. MECR encodes a 21.2 kDa protein that is composed of 189 amino acids; 10 peptides have been observed through mass spectrometry data.