MECR

Also known as CGI-63, FASN2B, NRBF1, mitochondrial trans-2-enoyl-CoA reductase, ETR1, DYTOABG

Trans-2-enoyl-CoA reductase, mitochondrial is an enzyme that in humans is encoded by the MECR gene.

Gene data

MECR

Name: mitochondrial trans-2-enoyl-CoA reductase
Type: protein-coding
Position: 29,192,657–29,230,945 (−)
Aliases: CGI-63, DYTOABG, ETR1, FASN2B, NRBF1, OPA16
Ensembl: ENSG00000116353
RefSeq RNA: NM_001024732.4, NM_001349711.2, NM_001349712.2, NM_001349713.2, NM_001349714.2
RefSeq protein: NP_001019903.3, NP_001336640.1, NP_001336641.1, NP_001336642.1, NP_001336643.1

The protein encoded by this gene is an oxidoreductase that catalyzes the last step in mitochondrial fatty acid synthesis. Defects in this gene are a cause of childhood-onset dystonia and optic atrophy. [provided by RefSeq, Mar 2017].

Gene Ontology

Biological process

fatty acid metabolic process fatty acid metabolic process

Article

6 sections

Contents

Structure
Function
Clinical significance
See also
References
Further reading

Trans-2-enoyl-CoA reductase, mitochondrial is an enzyme that in humans is encoded by the MECR gene.

== Structure == The MECR gene is located on the 1st chromosome, with its specific location being 1p35.3. The gene contains 15 exons. MECR encodes a 21.2 kDa protein that is composed of 189 amino acids; 10 peptides have been observed through mass spectrometry data.