menin
Sign in to saveAlso known as MEN1, uniprot:O00255, menin 1
Menin is a protein that in humans is encoded by the MEN1 gene. Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome) and has autosomal dominant inheritance. Variations in the MEN1 gene can cause pituitary adenomas, hyperparathyroidism, pancreatic neuroendocrine tumors, gastrinoma, and adrenocortical cancers.
Protein · UniProt
Menin
- Gene
- MEN1
- Organism
- Homo sapiens (Human)
- Length
- 610 aa
- Molecular mass
- 67,497 Da
- Evidence
- 1: Evidence at protein level
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation o…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
32 registered- PHASE2RECRUITINGA Phase II Study of the Menin Inhibitor Revumenib in Leukemia Associated With Upregulation of HOX GenesM.D. Anderson Cancer Center · NCT06229912
- PHASE1RECRUITINGSNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 MutationUma Borate · NCT06222580
- PHASE3RECRUITINGStudies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AMLKura Oncology, Inc. · NCT07007312
- PHASE1TERMINATEDStudy of Covalent Menin Inhibitor BMF-219 in Adult Patients With KRAS Driven Non-Small Cell Lung Cancer, Pancreatic Cancer, and Colorectal CancerBiomea Fusion Inc. · NCT05631574
- PHASE1/PHASE2RECRUITINGA Phase I-II Study Investigating the All-Oral Combination of the Menin Inhibitor SNDX-5613 With Decitabine/Cedazuridine (ASTX727) and Venetoclax in Acute Myeloid Leukemia (SAVE)M.D. Anderson Cancer Center · NCT05360160
- PHASE1/PHASE2COMPLETEDEvaluation of Revumenib in Participants With Colorectal Cancer and Other Solid TumorsSyndax Pharmaceuticals · NCT05731947
~7 min read
Article
9 sectionsContents
- History
- Genomics
- Clinical implications
- Role in cancer
- Pharmaceuticals
- Interactions
- References
- Further reading
- External links
Menin is a protein that in humans is encoded by the MEN1 gene. Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome) and has autosomal dominant inheritance. Variations in the MEN1 gene can cause pituitary adenomas, hyperparathyroidism, pancreatic neuroendocrine tumors, gastrinoma, and adrenocortical cancers.
In vitro studies have shown that menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD. However, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Two variants of the shorter transcript have been identified where alternative splicing affects the coding sequence. Five variants where alternative splicing takes place in the 5' UTR have also been identified.