MEPE
Sign in to saveAlso known as OF45, matrix extracellular phosphoglycoprotein
Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene. A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.
In the Vinony graph
Within Vinony's link graph, MEPE is referenced by 6 other articles, and connects out to PubMed, human chromosome 4 and Ensembl genome database project.
Vinony files it under Extracellular matrix proteins, Genes on human chromosome 4 and Protein pages needing a picture.
Its subject is documented across 6 Wikipedia language editions.
Gene data
MEPE- Name
- matrix extracellular phosphoglycoprotein
- Type
- protein-coding
- Position
- 87,821,398–87,846,814 (+)
- Aliases
- OF45
- Ensembl
- ENSG00000152595
- RefSeq RNA
- NM_001184694.3, NM_001184695.4, NM_001184696.2, NM_001184697.2, NM_001291183.2
- RefSeq protein
- NP_001171623.1, NP_001171624.1, NP_001171625.1, NP_001171626.1, NP_001278112.1
This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
matrix extracellular phosphoglycoprotein
- Symbol
- MEPE
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:87,821,398-87,846,814
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 9 more facts
- HomoloGene ID
- 10623
- chromosome
- human chromosome 4
- genetic association
- cardiovascular disease
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/56955
- genomic end
- 87846814
- genomic start
- 87821398
- cytogenetic location
- 4q22.1
- expressed in
- superior frontal gyrus
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene. A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.
==References==
Excerpted from Wikipedia’s “MEPE” article, available under the CC BY-SA 4.0 licence.