MESP2

Also known as SCDO2, bHLHc6, mesoderm posterior bHLH transcription factor 2

Mesoderm posterior protein 2 (MESP2), also known as class C basic helix-loop-helix protein 6 (bHLHc6), is a protein that in humans is encoded by the MESP2 gene.

In the Vinony graph

Vinony's link graph records 814 inbound references to MESP2, and connects out to PubMed, human chromosome 15 and Ensembl genome database project.

It sits within the topics Genes on human chromosome 15 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

MESP2

Name: mesoderm posterior bHLH transcription factor 2
Type: protein-coding
Position: 89,760,591–89,778,754 (+)
Aliases: SCDO2, bHLHc6
Ensembl: ENSG00000188095
RefSeq RNA: NM_001039958.2
RefSeq protein: NP_001035047.1

This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008].

Gene Ontology

Biological process

mesoderm formation heart morphogenesis regulation of transcription by RNA polymerase II somite rostral/caudal axis specification

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity protein dimerization activity sequence-specific double-stranded DNA binding sequence-specific double-stranded DNA binding

Cellular component

chromatin nucleus nucleus

Pathways

Developmental Biology Gastrulation Formation of paraxial mesoderm Somitogenesis Cardiac Progenitor Differentiation Gene regulatory network modelling somitogenesis Somitogenesis in the context of spondylocostal dysostosis

via MyGene.info

Gene · Ensembl

mesoderm posterior bHLH transcription factor 2

Symbol: MESP2
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:89,760,591-89,778,754
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 7420
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/145873
genomic end: 90321982
genomic start: 90303822
chromosome: human chromosome 15
cytogenetic location: 15q26.1
expressed in: nucleus accumbens

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Clinical significance
References
Further reading

Mesoderm posterior protein 2 (MESP2), also known as class C basic helix-loop-helix protein 6 (bHLHc6), is a protein that in humans is encoded by the MESP2 gene.

== Function ==

Excerpted from Wikipedia’s “MESP2” article, available under the CC BY-SA 4.0 licence.