MAPK8IP2

Also known as IB-2, IB2, JIP2, PRKM8IPL, mitogen-activated protein kinase 8 interacting protein 2

C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it. The gene is also known as Islet-Brain-2 (IB2).

Gene data

MAPK8IP2

Name: mitogen-activated protein kinase 8 interacting protein 2
Type: protein-coding
Aliases: IB-2, IB2, JIP2, PRKM8IPL

This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017].

via MyGene.info

Gene · Ensembl

mitogen-activated protein kinase 8 interacting protein 2

Symbol: MAPK8IP2
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:50,600,659-50,613,981
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 8201
exact match: identifiers.org/ncbigene/23542
genomic end: 51052409
genomic start: 50600793
cytogenetic location: 22q13.33

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Further reading

C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it. The gene is also known as Islet-Brain-2 (IB2).

This protein is highly expressed in the brain and is almost always deleted in Phelan-McDermid syndrome (PMS). MAPK8IP2 appears to regulate the ratio of AMPA receptors to NMDA receptors at glutamate synapses, and thus may be an important contributor to the intellectual dysfunction and related neurological manifestations characteristic of PMS.