MAPK8IP2

Also known as IB-2, IB2, JIP2, PRKM8IPL, mitogen-activated protein kinase 8 interacting protein 2

C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it. The gene is also known as Islet-Brain-2 (IB2).

In the Vinony graph

Vinony's link graph records 13 inbound references to MAPK8IP2, and connects out to PubMed, human chromosome 22 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 22.

Vinony links it to 5 Wikipedia language editions.

Gene data

MAPK8IP2

Name: mitogen-activated protein kinase 8 interacting protein 2
Type: protein-coding
Position: 50,600,659–50,613,981 (+)
Aliases: IB-2, IB2, JIP2, PRKM8IPL
Ensembl: ENSG00000008735
RefSeq RNA: NM_012324.6, NM_016431.3, NM_139124.1, XM_011530679.3, XM_011530680.3
RefSeq protein: NP_036456.1, XP_011528981.1, XP_011528982.1, XP_011528983.1, XP_054181338.1

This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017].

Pathways

MAPK signaling pathway - Homo sapiens (human)MAPK Signaling Pathway

via MyGene.info

Gene · Ensembl

mitogen-activated protein kinase 8 interacting protein 2

Symbol: MAPK8IP2
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:50,600,659-50,613,981
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 8201
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/23542
genomic end: 51052409
genomic start: 50600793
chromosome: human chromosome 22
cytogenetic location: 22q13.33
expressed in: Brodmann area 9

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Interactions
References
Further reading

C-jun-amino-terminal kinase-interacting protein 2 is a protein or the name of the gene that encodes it. The gene is also known as Islet-Brain-2 (IB2).

This protein is highly expressed in the brain and is almost always deleted in Phelan-McDermid syndrome (PMS). MAPK8IP2 appears to regulate the ratio of AMPA receptors to NMDA receptors at glutamate synapses, and thus may be an important contributor to the intellectual dysfunction and related neurological manifestations characteristic of PMS.

Excerpted from Wikipedia’s “MAPK8IP2” article, available under the CC BY-SA 4.0 licence.