methohexital
Also known as methohexitone, 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid, (+-)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid, alpha-DL-1-methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbituric acid, 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione, (+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid, Metohexital, 5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Methohexital or methohexitone (marketed under the brand names Brevital and Brietal) is a barbiturate derivative. It is classified as short-acting, and has a rapid onset of action. It is similar in its effects to sodium thiopental, a drug it competed with in the market for anesthetics.
Research
1,797 papers- Methohexital.International anesthesiology clinics · 1969
- Methohexital: a practical review for outpatient dental anesthesia.Anesthesia progress · 1991
- Narcotic drug methohexital: synthesis by enantioselective catalysis.Chirality · 2001
- Methohexital for procedural sedation of cardioversions in the emergency department.The American journal of emergency medicine · 2022
- Propofol Versus Methohexital in Electroconvulsive Therapy: Impact on Treatment Efficacy and Adverse Effects. A Systematic Literature Review and Meta-Analysis.Acta anaesthesiologica Scandinavica · 2025
via PubMed
~2 min read
Article
5 sectionsContents
- Pharmacology
- Indications
- Synthesis
- References
- External links
Methohexital or methohexitone (marketed under the brand names Brevital and Brietal) is a barbiturate derivative. It is classified as short-acting, and has a rapid onset of action. It is similar in its effects to sodium thiopental, a drug it competed with in the market for anesthetics.
==Pharmacology== Methohexital binds to a distinct site which is associated with Cl− ionophores at GABAA receptors. This increases the length of time which the Cl− ionopores are open, causing an inhibitory effect.