mitomycyna C

Also known as NSC-26980, MMC, 7-amino-9alpha-methoxymitosane, mitomycin C

związek chemiczny

In the Vinony graph

Vinony's link graph records 334 inbound references to mitomycyna C, and connects out to topical medication, antineoplastic and tiazofurin.

It is catalogued under topics including Antineoplastic drugs, Aziridines and Cancer treatments.

Vinony links it to 17 Wikipedia language editions.

Chemical data

Formula: C15H18N4O5
Molecular weight: 334.33 g/mol
IUPAC name: [(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
SMILES: CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
InChIKey: NWIBSHFKIJFRCO-WUDYKRTCSA-N
XLogP: -0.4
Polar surface area: 147 Å²
H-bond donors: 3
H-bond acceptors: 8
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1981
Admin. routes: parenteral, topical
Indications: neoplasm, Myopia, pterygium, sclerosing cholangitis

via ChEMBL · EBI

Research

24,627 papers

Mitomycin C.Cancer chemotherapy and biological response modifiers · 1990
Mitomycin C.Cancer chemotherapy and biological response modifiers · 1992
Mitomycin C.Cancer chemotherapy and biological response modifiers · 1988
Mitomycin-C in breast cancer.Seminars in oncology · 1985
Mitomycin C.Cancer chemotherapy and biological response modifiers · 1987

via PubMed

Wikidata facts

Mass: 334.12772
Has use: medication

Show 8 more facts

chemical formula: C₁₅H₁₈N₄O₅
medical condition treated: bladder cancer
subject has role: carcinogen
isomeric SMILES: CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
canonical SMILES: CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
different from: mitomycins
significant drug interaction: vinblastine
legal status (medicine): boxed warning

Sources (6)

via Wikidata · CC0

Article · Polski

Mitomycyna – organiczny związek chemiczny, inhibitor replikacji DNA wiążący się kowalencyjnie z matrycą DNA, co uniemożliwia jej rozplecenie. Lek jest stosowany w ogólnoustrojowym leczeniu nowotworów.

Abstract from DBpedia / Wikipedia · CC BY-SA