митомицин C

Also known as NSC-26980, MMC, 7-amino-9alpha-methoxymitosane, mitomycin C

химическое соединение

In the Vinony graph

Within Vinony's link graph, митомицин C is referenced by 334 other articles, and connects out to topical medication, antineoplastic and tiazofurin.

Vinony files it under Antineoplastic drugs, Aziridines and Cancer treatments.

Its subject is documented across 17 Wikipedia language editions.

Chemical data

Formula: C15H18N4O5
Molecular weight: 334.33 g/mol
IUPAC name: [(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
SMILES: CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
InChIKey: NWIBSHFKIJFRCO-WUDYKRTCSA-N
XLogP: -0.4
Polar surface area: 147 Å²
H-bond donors: 3
H-bond acceptors: 8
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1981
Admin. routes: parenteral, topical
Indications: neoplasm, Myopia, pterygium, sclerosing cholangitis

via ChEMBL · EBI

Research

24,627 papers

Mitomycin C.Cancer chemotherapy and biological response modifiers · 1990
Mitomycin C.Cancer chemotherapy and biological response modifiers · 1992
Mitomycin C.Cancer chemotherapy and biological response modifiers · 1988
Mitomycin-C in breast cancer.Seminars in oncology · 1985
Mitomycin C.Cancer chemotherapy and biological response modifiers · 1987

via PubMed

Wikidata facts

Mass: 334.12772
Has use: medication

Show 8 more facts

chemical formula: C₁₅H₁₈N₄O₅
medical condition treated: bladder cancer
subject has role: carcinogen
isomeric SMILES: CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
canonical SMILES: CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N
different from: mitomycins
significant drug interaction: vinblastine
legal status (medicine): boxed warning

Sources (6)

via Wikidata · CC0

Article · Русский

Митомицин С — цитостатический препарат из группы противоопухолевых антибиотиков. По химическому строению относится к . Обладает алкилирующим механизмом действия. Митомицин в форме порошка для инъекций включен в Перечень жизненно необходимых и важнейших лекарственных препаратов.

Abstract from DBpedia / Wikipedia · CC BY-SA