dirithromycin

Also known as Dynabac, Nortron, LY-237216

Dirithromycin is a macrolide glycopeptide antibiotic.

Key facts

Drug.Verifiedfields: changed
Drug.verifiedrevid: 460794200
Drug.IUPAC_name: (2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-9-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-3-ethyl-2,10-dihydroxy-7-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one
Drug.image: Dirithromycin.svg
Drug.image_class: skin-invert-image
Drug.width: 280
Drug.tradename: Dynabac
Drug.MedlinePlus: a604026
Drug.licence_US: Clarithromycin
Drug.pregnancy_category: B
Drug.routes_of_administration: Oral
Drug.bioavailability: 10%
Drug.protein_bound: 15 to 30%
Drug.metabolism: Hyrolized to erythromycyclamine in 1.5 hours
Drug.CAS_number: 62013-04-1
Drug.ATC_prefix: J01
Drug.ATC_suffix: FA13
Drug.PubChem: 6917067

via Wikipedia infobox

Research

166 papers

Dirithromycin: a new macrolide.The Annals of pharmacotherapy · 1996
Pharmacokinetics of dirithromycin.The Journal of antimicrobial chemotherapy · 1993
Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy.Drugs · 1994
Drug interactions of macrolides: emphasis on dirithromycin.The Annals of pharmacotherapy · 1997
Five-day dirithromycin therapy is as effective as seven-day erythromycin therapy for acute exacerbations of chronic bronchitis.The Journal of antimicrobial chemotherapy · 1999

via PubMed

Wikidata facts

Mass: 834.545305176

Show 4 more facts

chemical formula: C₄₂H₇₈N₂O₁₄
defined daily dose: 0.5
isomeric SMILES: CC[C@@H]1[C@@]([C@H]2[C@H]([C@H]([C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)OC)C)O[C@H]4[C@@H]([C@H](C[C@H](O4)C)N(C)C)O)(C)O)C)N[C@H](O2)COCCOC)C)(C)O
canonical SMILES: CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)(O)CC(C)C2NC(COCCOC)OC(C2C)C1(C)O

Sources (3)

via Wikidata · CC0

~4 min read

Article

2 sections

Contents

Discontinuation
References

{{Infobox drug | Verifiedfields = changed | verifiedrevid = 460794200 | IUPAC_name = (2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-9-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-3-ethyl-2,10-dihydroxy-7-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one | image = Dirithromycin.svg | image_class = skin-invert-image | width = 280